Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers
نویسندگان
چکیده
We describe a new functional group metathesis between aryl nitriles and thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good excellent yields. Furthermore, the cyanide- thiol-free reaction shows high tolerance great efficiency for late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility utility multistep synthesis.
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2021
ISSN: ['0002-7863', '1520-5126', '1943-2984']
DOI: https://doi.org/10.1021/jacs.1c00529